Yay! Slightly obscure meme question time!

This comic allegedly triggered a meme. Which?

Cracked by: Sumanth Patlolla, shrik, Manish Achuth, rohanquizzer, Vishwas B Sharma, Kaustabh Datta Choudhury, finkle, Rogi, Ananth, Bharath, Raghuvansh, rickde, badideabear, jowens, anurag and raklodramA