Yay! Obscure meme question time!

What meme did this cartoon supposedly trigger?

Cracked by: KK, Rosh, raklodramA, wanderlust, badideabear, Amarendra Kumar, Rogi, Sumanth Patlolla, Rahulk, Thejas V R, shrik, Siddarth Pai, Dibyo, jowens, Aditya S, Raghuvansh, Bharath, Ananth, Manish Achuth, Urthstripe, Logik and Shwetha Maiya